非天然的氨基酸納入多肽中基于許多不同的原因。例如,非自然氨基酸可用于提高多肽的活性或選擇性以及新藥開(kāi)發(fā)中多肽的等離子體穩(wěn)定性。
另外，使用非天然的氨基酸可誘導(dǎo)形成穩(wěn)定的二級(jí)結(jié)構(gòu)(螺旋，折疊)。
| β-Ala | 2-Abz | 7-AHP | Trp(Me) |
| β-Asp | 3-Abz | 8-AoC | Cys(lAA) |
| D-y-Glu | 4-Abz | 9-Anc | Ser(n-octanoyl) |
| y-Glu | Phe(3-Cl) | 10-Adc | Ser(Ac) |
| Cit | Phe(4-CI) | 12-Ado | L-Pen |
| D-Cit | D-Phe(4-Cl) | Dip | D-Pen |
| Tle | Phe(2-F) | D-Dip | AC3C/ACPC |
| Nva | Phe(3-F) | Bip | Sta |
| Nle | Phe(4-F) | D-Bip | Oic |
| D-Nle | Phe(4-Me) | Bal | D-0ic |
| Hyр | Phe(4-NO2) | Bpa | Thi |
| Orn | Phe(3-NO2) | D-Bpa | D-TiC |
| D-Orn | Phe(4-NH2) | 1-Nal | Tic |
| Ahx/Acp | Tyr(3-NO2) | 2-Nal | 2-Pal |
| Aib | Tyr(3-l) | D-2-Nal | 3-Pal |
| Abu | Tyr(3-Cl) | Cpa | 4-Pal |
| GABA/Y-Abu | Tyr(S03) | Cha | 4-Thiazolyalanine |
| DAP(Dnp)/Dpa | Tyr(Ac) | D-Cha | 9-AnthrylaAlanine |
| Dap | DOPA | D-Phg | 5-Methyl-L-norleucine |
| Dab | Dmt | Phg | L-Cyclopropylalanine |
| D-Dab | Phe(3,5-diF) | D-Chg | D-Cyclopropylalanine |
| Glp/Pyr | Thc/Thz | Chg | 1-aminocyclohexanecarboxylic acid |
| MMet(O) | Met(02) | ε-LyS | 1,2-Piperidinedicarboxylicacid |
